| http://purl.uniprot.org/citations/17420275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17420275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17420275 | http://www.w3.org/2000/01/rdf-schema#comment | "The induction of Bcl-x(L) is critical for the survival of late proerythroblasts. The erythroid-specific transcriptional network that regulates Bcl-x(L) expression in erythropoiesis remains unclear. The activation of the central erythropoietic transcriptional factor, GATA-1, leads to the early, transient induction of a transcription repressor, Gfi-1B, followed by the late induction of Bcl-x(L) during erythroid maturation in G1ER cells. Chromatin immunoprecipitation assays demonstrated that a constant level of GATA-1 binds to the Bcl-x promoter throughout the entire induction period, while Gfi-1B is transiently associated with the promoter in the early phase. The sustained expression of Gfi-1B abolished GATA-1-induced Bcl-x(L) expression. Here, we present evidence that GATA-1 binds to the noncanonical GATT motif of the Bcl-x promoter for trans-activation. Gfi-1B expressed at increased levels is recruited to the Bcl-x promoter through its association with GATA-1, suppressing Bcl-x(L) transcription. Therefore, the down-regulation of Gfi-1B in the late phase of erythroid maturation is necessary for Bcl-x(L) induction. Furthermore, we show that the inhibition of Bcr-Abl kinase by treatment with imatinib caused the up-regulation of Gfi-1B in K562 cells, where Gfi-1B also cooperated with GATA-1 to repress Bcl-x(L) transcription. Gfi-1B knockdown by RNA interference diminished imatinib-induced apoptosis, while the overexpression of Gfi-1B sensitized K562 cells to arsenic-induced death. These findings illuminate the role of Gfi-1B in GATA-1-mediated transcription in the survival aspect of erythroid cells."xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.02212-06"xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.02212-06"xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/author | "Chang Z.-F."xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/author | "Chang Z.-F."xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/author | "Kuo Y.-Y."xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/author | "Kuo Y.-Y."xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/pages | "4261-4272"xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/pages | "4261-4272"xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/title | "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription."xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/title | "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription."xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17420275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17420275 |
| http://purl.uniprot.org/citations/17420275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17420275 |
| http://purl.uniprot.org/citations/17420275 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17420275 |
| http://purl.uniprot.org/citations/17420275 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17420275 |
| http://purl.uniprot.org/uniprot/Q5VTD9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17420275 |
| http://purl.uniprot.org/uniprot/P15976 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17420275 |