| http://purl.uniprot.org/citations/17420281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17420281 | http://www.w3.org/2000/01/rdf-schema#comment | "Par 6 acts as a scaffold protein to facilitate atypical protein kinase C-mediated phosphorylation of cytoplasmic protein complexes, leading to epithelial and neuronal cell polarization. In addition to its location in the cytoplasm, Par 6 is localized to the nucleus. However, its organization and potential functions in the nucleus have not been examined. Using an affinity-purified Par 6 antibody and a chimera of Par 6 and green fluorescent protein, we show that Par 6 localizes precisely to nuclear speckles, but not to other nuclear structures, and displays characteristics of speckle proteins. We show that Par 6 colocalizes in the nucleus with Tax, a transcriptional activator of the human T-cell leukemia virus type 1 long terminal repeat, but multiple lines of evidence show that Par 6 is not directly involved in known functions of speckle proteins, including general transcription, splicing, or mRNA transport. Significantly, however, the structure of nuclear speckles is lost when Par 6 levels are reduced by Par 6-specific small interfering RNA. Therefore, we hypothesize that Par 6 in the nucleus acts as a scaffolding protein in nuclear speckle complexes, similar to its role in the cytoplasm."xsd:string |
| http://purl.uniprot.org/citations/17420281 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.02235-06"xsd:string |
| http://purl.uniprot.org/citations/17420281 | http://purl.uniprot.org/core/author | "Nelson W.J."xsd:string |
| http://purl.uniprot.org/citations/17420281 | http://purl.uniprot.org/core/author | "Cline E.G."xsd:string |
| http://purl.uniprot.org/citations/17420281 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17420281 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17420281 | http://purl.uniprot.org/core/pages | "4431-4443"xsd:string |
| http://purl.uniprot.org/citations/17420281 | http://purl.uniprot.org/core/title | "Characterization of mammalian Par 6 as a dual-location protein."xsd:string |
| http://purl.uniprot.org/citations/17420281 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17420281 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17420281 |
| http://purl.uniprot.org/citations/17420281 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17420281 |
| http://purl.uniprot.org/uniprot/#_Q9NPB6-mappedCitation-17420281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17420281 |
| http://purl.uniprot.org/uniprot/Q9NPB6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17420281 |