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http://purl.uniprot.org/citations/17420351http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17420351http://www.w3.org/2000/01/rdf-schema#comment"

Background

Atherosclerosis is an immunoinflammatory disease; however, the key factors responsible for the maintenance of immune regulation in a proinflammatory milieu are poorly understood.

Methods and results

Here, we show that milk fat globule-EGF factor 8 (Mfge8, also known as lactadherin) is expressed in normal and atherosclerotic human arteries and is involved in phagocytic clearance of apoptotic cells by peritoneal macrophages. Disruption of bone marrow-derived Mfge8 in a murine model of atherosclerosis leads to substantial accumulation of apoptotic debris both systemically and within the developing lipid lesions. The accumulation of apoptotic material is associated with a reduction in interleukin-10 in the spleen but an increase in interferon-gamma production in both the spleen and the atherosclerotic arteries. In addition, we report a dendritic cell-dependent alteration of natural regulatory T-cell function in the absence of Mfge8. These events are associated with a marked acceleration of atherosclerosis.

Conclusions

Lack of Mfge8 in bone marrow-derived cells enhances the accumulation of apoptotic cell corpses in atherosclerosis and alters the protective immune response, which leads to an acceleration of plaque development."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.org/dc/terms/identifier"doi:10.1161/circulationaha.106.662080"xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Kinugawa K."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Zoll J."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Simon T."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Heeneman S."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Mallat Z."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Blanc-Brude O."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Boddaert J."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Merval R."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Tedgui A."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Daemen M.J."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Boulanger C."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Esposito B."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Teissier E."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Leseche G."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Potteaux S."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Ait-Oufella H."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/author"Barateau V."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/name"Circulation"xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/pages"2168-2177"xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/title"Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice."xsd:string
http://purl.uniprot.org/citations/17420351http://purl.uniprot.org/core/volume"115"xsd:string
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