| http://purl.uniprot.org/citations/17426287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17426287 | http://www.w3.org/2000/01/rdf-schema#comment | "The calcium-sensing receptor (CaR) helps to maintain the homeostasis of extracellular calcium by controlling the secretion of hormones associated with this process. The mechanism of agonist-induced endocytosis and down-regulation of CaR and the influence of this event on the secretion of CaR-regulated hormones is not fully understood. In this study, we show that CaR is constitutively endocytosed and recycled to the plasma membrane by a Rab11a-dependent mechanism; during this process, the level of total cellular CaR is maintained. This trafficking of CaR promotes the secretion of PTH-related peptide (PTHrP), as evidenced by a decrease on PTHrP secretion in the presence of a dominant-negative mutant of Rab11a. Interestingly, this Rab11a dominant-negative mutant does not interfere with CaR-dependent activation of ERK 1/2, suggesting that ERK signaling is not sufficient to promote PTHrP secretion downstream of CaR. In addition, AMSH (associated molecule with the SH3 domain of STAM), a CaR carboxyl-terminal binding protein, redirects CaR from slow recycling to down-regulation, reducing CaR expression and decreasing PTHrP secretion. Our results indicate that endocytosis and trafficking of CaR modulate PTHrP secretion."xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2006-0523"xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/author | "Vazquez-Prado J."xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/author | "Reyes-Cruz G."xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/author | "Valadez-Sanchez M."xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/author | "Esparza-Silva A.L."xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/author | "Garcia-Regalado A."xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/author | "Ramirez-Rangel I."xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/author | "Reyes-Ibarra A.P."xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/pages | "1394-1407"xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/title | "Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism."xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/17426287 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17426287 |
| http://purl.uniprot.org/citations/17426287 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17426287 |
| http://purl.uniprot.org/uniprot/#_A0MJX3-mappedCitation-17426287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17426287 |
| http://purl.uniprot.org/uniprot/#_A0MJX4-mappedCitation-17426287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17426287 |
| http://purl.uniprot.org/uniprot/#_A0MJX5-mappedCitation-17426287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17426287 |
| http://purl.uniprot.org/uniprot/#_A0MJX6-mappedCitation-17426287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17426287 |
| http://purl.uniprot.org/uniprot/#_B3KS69-mappedCitation-17426287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17426287 |
| http://purl.uniprot.org/uniprot/#_B3KR00-mappedCitation-17426287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17426287 |
| http://purl.uniprot.org/uniprot/#_B4DMN1-mappedCitation-17426287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17426287 |
| http://purl.uniprot.org/uniprot/#_B4DQU5-mappedCitation-17426287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17426287 |