| http://purl.uniprot.org/citations/17433643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17433643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17433643 | http://www.w3.org/2000/01/rdf-schema#comment | "Tuberculosis is a chronic infectious disease caused by bacteria of the Mycobacterium tuberculosis complex. One of the major contributors to virulence and intercellular spread of M. tuberculosis is the ESAT-6 secretion system 1 (ESX-1) that has been lost by the live vaccines Mycobacterium bovis BCG (Bacille Calmette Guérin) and Mycobacterium microti as a result of independent deletions. ESX-1 consists of at least 10 genes (Rv3868-Rv3877) encoding the T-cell antigens ESAT-6 and CFP-10 as well as AAA-ATPases, chaperones, and membrane proteins which probably form a novel export system. To better understand the mode of action of the ESX-1 proteins, as a prelude to drug development, we examined systematically the interactions between the various proteins using the two-hybrid system in Saccharomyces cerevisiae. Interestingly, ESAT-6 and CFP-10 formed both hetero- and homodimers. Moreover, Rv3866, Rv3868, and CFP-10 interacted with Rv3873 which also homodimerized. The data were summarized in a protein linkage map that is consistent with the model for the secretion apparatus and can be used as a basis to identify inhibitors of specific interactions."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.micres.2006.11.016"xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.micres.2006.11.016"xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Cole S.T."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Cole S.T."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Munder T."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Munder T."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Schumann G."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Schumann G."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Mollmann U."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Mollmann U."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Grabley S."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Grabley S."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Teutschbein J."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/author | "Teutschbein J."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/name | "Microbiol. Res."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/name | "Microbiol. Res."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/pages | "253-259"xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/pages | "253-259"xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/title | "A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/17433643 | http://purl.uniprot.org/core/title | "A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis."xsd:string |