| http://purl.uniprot.org/citations/17434926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17434926 | http://www.w3.org/2000/01/rdf-schema#comment | "The bitter acids of hops (Humulus lupulus L.) mainly consist of humulones or alpha-acids and lupulones or beta-acids. We aimed to evaluate the antiproliferative mechanisms of lupulones on a human metastatic colon carcinoma-derived cell line (SW620 cells) and to assess their chemopreventive effects in a model of colon carcinogenesis. SW620 cell growth was inhibited by 70% after a 48 h exposure to lupulones (40 microg/ml). Lupulones up-regulated the expression of Fas receptor (Fas) and Fas ligand (FasL) as well as TNF-related apoptosis inducing ligand (TRAIL)-R1 (DR4) and -R2 (DR5) receptor proteins, suggesting the involvement of Fas and TRAIL receptors-mediated pathways in lupulone-induced apoptosis. Lupulones also increased the mitochondrial membrane permeability. Colon carcinogenesis was initiated in Wistar rats by intra-peritoneal injections of azoxymethane (AOM), once a week for 2 weeks. One week after the last injection, rats received lupulones (0.001 or 0.005%) in drinking water, and AOM-control rats received the excipient. After 7 months of treatment, the colon of rats receiving 0.001 and 0.005% lupulones showed, respectively, a 30 and a 50% reduction (P < 0.05) of the number of preneoplastic lesions (aberrant crypt foci). In addition, we observed a drastic reduction (70-80%) of the total number of tumors in the colon of rats treated with lupulones when compared with the AOM control group. Lupulones induced apoptosis in SW620 colon-derived metastatic cells by activating both Fas and TRAIL death receptor signaling pathways, and antagonize at a low dose (4 mg/kg/day) colon cancer development. These observations suggest the use of lupulones for colon cancer chemoprevention trials."xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgm080"xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/author | "Roussi S."xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/author | "Raul F."xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/author | "Chaabi M."xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/author | "Gosse F."xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/author | "Lamy V."xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/author | "Lobstein A."xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/author | "Schall N."xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/pages | "1575-1581"xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/title | "Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/17434926 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17434926 |
| http://purl.uniprot.org/citations/17434926 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17434926 |
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