| http://purl.uniprot.org/citations/17435766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17435766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17435766 | http://www.w3.org/2000/01/rdf-schema#comment | "H-NS is a protein of the bacterial nucleoid involved in DNA compaction and transcription regulation. In vivo, H-NS selectively silences specific genes of the bacterial chromosome. However, many studies have concluded that H-NS binds sequence-independently to DNA, leaving the molecular basis for its selectivity unexplained. We show that the negative regulatory element (NRE) of the supercoiling-sensitive Escherichia coliproU gene contains two identical high-affinity binding sites for H-NS. Cooperative binding of H-NS is abrogated by changes in DNA superhelical density and temperature. We further demonstrate that the high-affinity sites nucleate cooperative binding and establish a nucleoprotein structure required for silencing. Mutations in these sites result in loss of repression by H-NS. In this model, silencing at proU, and by inference at other genes directly regulated by H-NS, is tightly controlled by the cooperativity between bound H-NS molecules."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1233"xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1233"xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/author | "Travers A."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/author | "Travers A."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/author | "Badaut C."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/author | "Badaut C."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/author | "Rimsky S."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/author | "Rimsky S."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/author | "Bouffartigues E."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/author | "Bouffartigues E."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/author | "Buckle M."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/author | "Buckle M."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/pages | "441-448"xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/pages | "441-448"xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/title | "H-NS cooperative binding to high-affinity sites in a regulatory element results in transcriptional silencing."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/title | "H-NS cooperative binding to high-affinity sites in a regulatory element results in transcriptional silencing."xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/17435766 | http://purl.uniprot.org/core/volume | "14"xsd:string |