http://purl.uniprot.org/citations/17437273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/17437273 | http://www.w3.org/2000/01/rdf-schema#comment | "Human T-lymphotropic virus-I (HTLV-I) causes adult T-cell leukemia/lymphoma (ATL) and HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class-I (A,B) and class-II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM/TSP patients and 190 population-based, asymptomatic HTLV-I-infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence >50% of asymptomatic carriers) and by prevalence quartile. HTLV-I proviral load between asymptomatic carriers with common versus uncommon types was compared by t-test. ATL differed from asymptomatic carriers in overall DQB1 allele and class-I haplotype frequencies (p == 0.04). ATL risk was increased significantly with common HLA-B (OR 2.25, 95% CI 1.19-4.25) and DRB1 (OR 2.11, 95% CI 1.13-3.40) alleles. Higher prevalence HLA-B alleles were associated with higher ATL risk (OR 1.14 per quartile, p(trend) = 0.02). Asymptomatic carriers with common HLA-B alleles had marginally higher HTLV-I proviral load (p = 0.057). HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA-B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia/lymphoma."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.22767"xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Carrington M."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Kim N."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Li H.C."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Hisada M."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Chatterjee N."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Morgan O."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Goedert J.J."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Sonoda S."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Gao X.J."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Biggar R.J."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Cranston B."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/author | "Hanchard B."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/pages | "1092-1097"xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/title | "Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types."xsd:string |
http://purl.uniprot.org/citations/17437273 | http://purl.uniprot.org/core/volume | "121"xsd:string |
http://purl.uniprot.org/citations/17437273 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17437273 |
http://purl.uniprot.org/citations/17437273 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17437273 |
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-17437273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17437273 |
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-17437273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17437273 |
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-17437273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17437273 |