| http://purl.uniprot.org/citations/17438065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17438065 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon (IFN)-gamma, a cytokine critical for resistance to infection and tumors, is produced by CD4(+) helper T lymphocytes after stimulation by cultured dendritic cells (DCs) that secrete a cofactor, interleukin (IL)-12. We have identified a major IL-12-independent pathway whereby DCs induce IFN-gamma-secreting T helper (Th)1 CD4(+) T cells in vivo. This pathway requires the membrane-associated tumor necrosis family member CD70 and was identified by targeting the LACK antigen from Leishmania major within an antibody to CD205 (DEC-205), an uptake receptor on a subset of DCs. Another major DC subset, targeted with 33D1 anti-DCIR2 antibody, also induced IFN-gamma in vivo but required IL-12, not CD70. Isolated CD205(+) DCs expressed cell surface CD70 when presenting antigen to T cell receptor transgenic T cells, and this distinction was independent of maturation stimuli. CD70 was also essential for CD205(+) DC function in vivo. Detection of the IL-12-independent IFN-gamma pathway was obscured with nontargeted LACK, which was presented by both DC subsets. This in situ analysis points to CD70 as a decision maker for Th1 differentiation by CD205(+) DCs, even in Th2-prone BALB/c animals and potentially in vaccine design. The results indicate that two DC subsets have innate propensities to differentially affect the Th1/Th2 balance in vivo and by distinct mechanisms."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20070176"xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/author | "Glaichenhaus N."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/author | "Mougneau E."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/author | "Soares H."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/author | "Dudziak D."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/author | "Steinman R.M."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/author | "Nussenzweig M.C."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/author | "Waechter H."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/author | "Mizenina O."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/pages | "1095-1106"xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/title | "A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo."xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/17438065 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17438065 |
| http://purl.uniprot.org/citations/17438065 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17438065 |
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| http://purl.uniprot.org/uniprot/#_C4NUM1-mappedCitation-17438065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17438065 |
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