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http://purl.uniprot.org/citations/17439630http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17439630http://www.w3.org/2000/01/rdf-schema#comment"

Background

The factor V Leiden (FVL) and prothrombin 20210A (PTm) mutations are associated with single late pregnancy loss and recurrent early pregnancy loss. The prognosis after an initial loss in women with thrombophilia is uncertain.

Objective

To assess the pregnancy outcome of the second pregnancy after a first loss in women with and without either FVL or PTm mutations.

Methods

We selected women with a first pregnancy loss out of two family cohorts of first degree relatives of probands with FVL or PTm mutations and a history of documented venous thromboembolism or premature atherosclerosis.

Results

Ninety-three women had had a first pregnancy loss and became pregnant a second time. Their risk of loss of the subsequent pregnancy was higher than in 825 women with a successful first pregnancy [25 vs. 12%, relative risk (RR) 2.0, 95% CI 1.4-3.0]. The live birth rate of the second pregnancy after an early first loss ( 12 weeks), the live birth rates were 68% (95% CI 46-85) and 80% (95% CI 49-94) for carriers and non-carriers, respectively (RR 0.9, 95% CI 0.5-1.3).

Conclusions

Women with a first pregnancy loss have a 2-fold increased risk of loss of the subsequent pregnancy, regardless of their carrier status. More importantly, the outcome of the second pregnancy is rather favorable in absolute terms, even for those with thrombophilia and a late loss, which raises concern regarding the risks and presumed benefits of anticoagulant therapy in these women."xsd:string
http://purl.uniprot.org/citations/17439630http://purl.org/dc/terms/identifier"doi:10.1111/j.1538-7836.2007.02586.x"xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/author"van der Meer J."xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/author"Coppens M."xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/author"Prins M.H."xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/author"Middeldorp S."xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/author"Buller H.R."xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/author"Hamulyak K."xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/author"Folkeringa N."xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/author"Teune M.J."xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/name"J Thromb Haemost"xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/pages"1444-1448"xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/title"Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutations."xsd:string
http://purl.uniprot.org/citations/17439630http://purl.uniprot.org/core/volume"5"xsd:string
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http://purl.uniprot.org/uniprot/#_C8C1T1-mappedCitation-17439630http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17439630
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