| http://purl.uniprot.org/citations/17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17439939 | http://www.w3.org/2000/01/rdf-schema#comment | "Male mice lacking ADAM2 (fertilin beta) or ADAM3 (cyritestin) are infertile; cauda epididymal sperm (mature sperm) from these mutant mice cannot bind to the egg zona pellucida. ADAM3 is barely present in Adam2-null sperm, despite normal levels of this protein in Adam2-null testicular germ cells (TGCs; sperm precursor cells). Here, we have explored the molecular basis for the loss of ADAM3 in Adam2-null TGCs to clarify the biosynthetic and functional linkage of ADAM2 and ADAM3. A small portion of total ADAM3 was found present on the surface of wild-type and Adam2(-/-) TGCs at similar levels. In the Adam2-null TGCs, however, surface-localized ADAM3 exhibited an increased amount of an endoglycosidase H-resistant form that may be related to instability of ADAM3. Moreover, we found a complex between ADAM2 and ADAM3 on the surface of TGCs and sperm. The intracellular chaperone calnexin was a component of the testicular ADAM2-ADAM3 complex. Our findings suggest that the association with ADAM2 is a key element for stability of ADAM3 in epididymal sperm. The presence of the ADAM2-ADAM3 complex in sperm also suggests a potential role of ADAM2 with ADAM3 in sperm binding to the egg zona pellucida."xsd:string |
| http://purl.uniprot.org/citations/17439939 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m702268200"xsd:string |
| http://purl.uniprot.org/citations/17439939 | http://purl.uniprot.org/core/author | "Nishimura H."xsd:string |
| http://purl.uniprot.org/citations/17439939 | http://purl.uniprot.org/core/author | "Myles D.G."xsd:string |
| http://purl.uniprot.org/citations/17439939 | http://purl.uniprot.org/core/author | "Primakoff P."xsd:string |
| http://purl.uniprot.org/citations/17439939 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17439939 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17439939 | http://purl.uniprot.org/core/pages | "17900-17907"xsd:string |
| http://purl.uniprot.org/citations/17439939 | http://purl.uniprot.org/core/title | "Identification of an ADAM2-ADAM3 complex on the surface of mouse testicular germ cells and cauda epididymal sperm."xsd:string |
| http://purl.uniprot.org/citations/17439939 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17439939 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17439939 |
| http://purl.uniprot.org/citations/17439939 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17439939 |
| http://purl.uniprot.org/uniprot/#_E9QA56-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_F8VQ03-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_E9PYS3-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_E9PYS9-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_F6TMV4-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_Q62287-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_Q60718-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_Q3TTP6-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_Q78ZE8-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_Q810R6-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_Q6P907-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |
| http://purl.uniprot.org/uniprot/#_S5MGA4-mappedCitation-17439939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17439939 |