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http://purl.uniprot.org/citations/17442187http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17442187http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The 4- and 16-hydroxylated metabolites of estrogens have been implicated in carcinogenesis, whereas its 2-hydroxylated metabolites have been shown to have antiangiogenic effects. We aimed to examine whether the polymorphisms of catechol-O-methyltransferase (COMT) involved in the estrogen metabolism are associated with endometrial cancer risk.

Methods

Polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) analysis was used to study the variant allele frequency distributions of COMT Val158Met genetic polymorphism in a population based case-control study with 132 endometrial cancer cases and 110 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression after adjustment for known or suspected risk factors for endometrial cancer.

Results

The most frequent genotype was COMT(Val/Val) (47.2%, 52/110) in control group and COMT(Val/Met) (58.3%, 77/132) in endometrial cancer group. The difference between the two groups was of statistical significance (P < 0.05). Compared with COMT(Met/Met) genotype, the COMT(Val/Val) genotype was inversely correlated with endometrial cancer risk, and the adjusted OR value was 0.262 (95% CI: 0.080 - 0.862, P = 0.027).

Conclusions

Among the genotypes in women in South China, genotype COMT(Val/Val) is mostly seen, followed by COMT(Val/Met), and COMT(Met/Met) is the least in control group. The endometrial cancer susceptivity of genotype COMT(Val/Val) carriers may be lower than COMT(Met/Met) carriers."xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/author"Li S.J."xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/author"Zhuang Y.Y."xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/author"Zhao X.M."xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/author"Xie M.Q."xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/author"Tang X.L."xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/author"Yang D.Z."xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/author"Wang L.A."xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/name"Zhonghua Fu Chan Ke Za Zhi"xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/pages"116-119"xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/title"[Polymorphism of catechol-O-methyltransferase gene in relation to the risk of endometrial cancer]."xsd:string
http://purl.uniprot.org/citations/17442187http://purl.uniprot.org/core/volume"42"xsd:string
http://purl.uniprot.org/citations/17442187http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17442187
http://purl.uniprot.org/citations/17442187http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17442187
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