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http://purl.uniprot.org/citations/17442310http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17442310http://www.w3.org/2000/01/rdf-schema#comment"We investigated the expression of formyl peptide receptor (FPR) and its functional role in human bone marrow-derived mesenchymal stem cells (MSCs). We analyzed the expression of FPR by using ligand-binding assay with radio-labeled N-formyl-met-leu-phe (fMLF), and found that MSCs express FPR. FMLF stimulated intracellular calcium increase, mitogen-activated protein kinases activation, and Akt activation, which were mediated by G(i) proteins. MSCs were chemotactically migrated to fMLF. FMLF-induced MSC chemotaxis was also completely inhibited by pertussis toxin, LY294002, and PD98059, indicating the role of G(i) proteins, phosphoinositide 3-kinase, and extracellular signal regulated protein kinase. N-terminal fragment of annexin-1, Anx-1(2-26), an endogenous agonist for FPR, also induced chemotactic migration of MSCs. Thus MSCs express functional FPR, suggesting a new (patho)physiological role of FPR and its ligands in regulating MSC trafficking during induction of injured tissue repair."xsd:string
http://purl.uniprot.org/citations/17442310http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2007.03.078"xsd:string
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/author"Kim J.H."xsd:string
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/author"Park Y.J."xsd:string
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/author"Kim M.K."xsd:string
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/author"Bae Y.S."xsd:string
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/author"Ryu S.H."xsd:string
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/author"Min d.o. S."xsd:string
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/name"FEBS Lett"xsd:string
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/pages"1917-1922"xsd:string
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/title"Expression and functional role of formyl peptide receptor in human bone marrow-derived mesenchymal stem cells."xsd:string
http://purl.uniprot.org/citations/17442310http://purl.uniprot.org/core/volume"581"xsd:string
http://purl.uniprot.org/citations/17442310http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17442310
http://purl.uniprot.org/citations/17442310http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17442310
http://purl.uniprot.org/uniprot/#_B2RC44-mappedCitation-17442310http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17442310
http://purl.uniprot.org/uniprot/#_P21462-mappedCitation-17442310http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17442310
http://purl.uniprot.org/uniprot/P21462http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17442310
http://purl.uniprot.org/uniprot/B2RC44http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17442310