| http://purl.uniprot.org/citations/17442726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17442726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17442726 | http://www.w3.org/2000/01/rdf-schema#comment | "An electroneutral organic cation (OC)/proton exchanger in the apical membrane of proximal tubules mediates the final step of renal OC excretion. Two members of the multidrug and toxin extrusion family, MATE1 and MATE2-K, were recently identified in human and rodent kidney and proposed to be the molecular basis of renal OC/H(+) exchange. To take advantage of the comparative value of the large database on the kinetic and selectivity characteristics of OC/H(+) exchange that exists for rabbit kidney, we cloned rbMATE1 and rbMATE2-K. The rabbit homologs have 75% (MATE1) and 74% (MATE2-K) amino acid identity to their human counterparts (and 51% identity with each other). rbMATE1 and rbMATE2-K exhibited H(+) gradient-dependent uptake and efflux of tetraethylammonium (TEA) when expressed in Chinese hamster ovary cells. Both transporters displayed similar affinities for selected compounds [IC(50) values within 2-fold for TEA, 1-methyl-4-phenylpyridinium, and quinidine] and very different affinities for others (IC(50) values differing by 8-to 80-fold for choline and cimetidine, respectively). These results indicate that rbMATE1 and rbMATE2-K are multispecific OC/H(+) exchangers with similar, but distinct, functional characteristics. Overall, the selectivity of MATE1 and MATE2-K correlated closely with that observed in rabbit renal brush-border membrane vesicles."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.00102.2007"xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.00102.2007"xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/author | "Cherrington N.J."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/author | "Cherrington N.J."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/author | "Wright S.H."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/author | "Wright S.H."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/pages | "F360-F370"xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/pages | "F360-F370"xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/title | "Molecular identification and functional characterization of rabbit MATE1 and MATE2-K."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/title | "Molecular identification and functional characterization of rabbit MATE1 and MATE2-K."xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/17442726 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17442726 |
| http://purl.uniprot.org/citations/17442726 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17442726 |
| http://purl.uniprot.org/citations/17442726 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17442726 |
| http://purl.uniprot.org/citations/17442726 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17442726 |