| http://purl.uniprot.org/citations/17442938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17442938 | http://www.w3.org/2000/01/rdf-schema#comment | "B7-1 and B7-2 play different roles in the pathogenesis of autoimmunity, but this is controversial. We analyzed colitis induced by transfer of CD45RB(high)CD4(+) T cells to RAG(-/-) recipients lacking B7-1 and/or B7-2. Surprisingly, disease was greatly accelerated in RAG(-/-) recipients deficient for either B7-1 or B7-2, especially in the B7-2(-/-) recipients. This accelerated colitis induction correlated with increased T cell division in vivo and production of Th1 cytokines. Although colitis pathogenesis following T cell transfer was inhibited in the absence of CD40L expression, CD40-CD40L interactions were not required in the B7-2(-/-) RAG(-/-) recipients. In vitro priming by APCs lacking either B7-1 or B7-2 caused decreased IL-2 production, which led to decreased CTLA-4 expression, although T cells primed in this way could respond vigorously upon restimulation by producing increased IL-2 and proinflammatory cytokines. Consistent with this mechanism, we demonstrate that blocking IL-2 early after T cell transfer accelerated colitis. Our data therefore outline a mechanism whereby synergistic costimulation by B7-1 and B7-2 molecules during priming is required for optimal IL-2 production. The consequent inhibitory effect of full CTLA-4 expression, induced by IL-2, may slow colitis, even in the absence of regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/17442938 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.9.5563"xsd:string |
| http://purl.uniprot.org/citations/17442938 | http://purl.uniprot.org/core/author | "Levin M."xsd:string |
| http://purl.uniprot.org/citations/17442938 | http://purl.uniprot.org/core/author | "Sharpe A."xsd:string |
| http://purl.uniprot.org/citations/17442938 | http://purl.uniprot.org/core/author | "Kim G."xsd:string |
| http://purl.uniprot.org/citations/17442938 | http://purl.uniprot.org/core/author | "Kronenberg M."xsd:string |
| http://purl.uniprot.org/citations/17442938 | http://purl.uniprot.org/core/author | "Schoenberger S.P."xsd:string |
| http://purl.uniprot.org/citations/17442938 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17442938 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17442938 | http://purl.uniprot.org/core/pages | "5563-5570"xsd:string |
| http://purl.uniprot.org/citations/17442938 | http://purl.uniprot.org/core/title | "Paradoxical effect of reduced costimulation in T cell-mediated colitis."xsd:string |
| http://purl.uniprot.org/citations/17442938 | http://purl.uniprot.org/core/volume | "178"xsd:string |
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