| http://purl.uniprot.org/citations/17446930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17446930 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined the role of p38alpha MAPK in mediating cardiomyopathy in mice overexpressing beta(1)-adrenergic receptor (beta(1)-AR) or beta(2)-AR by mating them with dominant-negative p38alpha (DNp38alpha) MAPK mice. Both beta(1)-AR and beta(2)-AR Tg mice had enhanced LV ejection fraction (LVEF) as young adults and developed similar cardiomyopathy at 11-15 months, characterized by reduced LVEF, myocyte hypertrophy, fibrosis, and apoptosis. We inhibited p38alpha MAPK by mating beta(1)-AR Tg and beta(2)-AR Tg mice with DNp38alpha MAPK mice, which rescued the depressed LVEF and reduced apoptosis and fibrosis in bigenic beta(2)-AR x DNp38alpha MAPK mice, but not bigenic beta(1)-AR x DNp38alpha MAPK mice, and failed to reduce myocyte hypertrophy in either group. G(salpha) was increased in both beta(1)-AR Tg and beta(2)-AR Tg mice and was still present in bigenic beta(1)-AR x DNp38alpha MAPK mice, but not bigenic beta(2)-AR x DNp38alpha MAPK mice. This suggests that p38alpha MAPK is one critical downstream signal for the development of cardiomyopathy following chronic beta(2)-AR stimulation, but other kinases may be more important in ameliorating the adverse effects of chronic beta(1)-AR stimulation."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci29576"xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/author | "Yan L."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/author | "Engelhardt S."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/author | "Sadoshima J."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/author | "Vatner S.F."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/author | "Vatner D.E."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/author | "Brady J.E."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/author | "Peter P.S."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/pages | "1335-1343"xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/title | "Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor."xsd:string |
| http://purl.uniprot.org/citations/17446930 | http://purl.uniprot.org/core/volume | "117"xsd:string |
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