| http://purl.uniprot.org/citations/17452529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17452529 | http://www.w3.org/2000/01/rdf-schema#comment | "Elucidation of mechanisms regulating cell cycle progression is of fundamental importance for cell and cancer biology. Although several genes and signaling pathways are implicated in G1-S regulation, less is known regarding the mechanisms controlling cell cycle progression through G2 and M phases. We report that extracellular signal-regulated kinase 5 (ERK5), a member of the mitogen-activated protein kinases, is activated at G2-M and required for timely mitotic entry. Stimulation of ERK5 activated nuclear factor kappaB (NFkappaB) through ribosomal S6 kinase 2 (RSK2)-mediated phosphorylation and degradation of IkappaB. Furthermore, selective inhibition of NFkappaB at G2-M phases substantially delayed mitotic entry and inhibited transcription of G2-M-specific genes, including cyclin B1, cyclin B2, Plk-1, and cdc25B. Moreover, inhibition of NFkappaB at G2-M diminished mitosis induced by constitutive activation of ERK5, providing a direct link between ERK5, NFkappaB, and regulation of G2-M progression. We conclude that a novel ERK5-NFkappaB signaling pathway plays a key role in regulation of the G2-M progression."xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200609166"xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/author | "Choi H.J."xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/author | "Wang C.Y."xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/author | "Xia Z."xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/author | "Hsuan S.L."xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/author | "Cude K."xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/pages | "253-264"xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/title | "Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/17452529 | http://purl.uniprot.org/core/volume | "177"xsd:string |
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