| http://purl.uniprot.org/citations/17454138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17454138 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear factor-kappaB (NF-kappaB) has a dual role in the promotion or attenuation of cell death. Here, we demonstrated the role of NF-kappaB in the H(2)O(2)-induced death of astrocytes. H(2)O(2) evoked the release of lactate dehydrogenase (LDH), a marker of cell death, and concomitantly decreased the DNA binding and transcriptional activity of NF-kappaB in cultured astrocytes. H(2)O(2)-induced astrocyte death was markedly increased by the co-treatment with pyrrolidinedithiocarbamate, an NF-kappaB inhibitor. Moreover, the elevation of constitutive NF-kappaB activity by overexpressing p65 NF-kappaB subunit attenuated H(2)O(2) toxicity, whereas NF-kappaB inhibition by overexpressing IkappaB potentiated the toxicity. NF-kappaB activity and H(2)O(2) cytotoxicity was further found to be dependent on cell density. Compared with astrocytes in low cell density, those in high cell density exhibited a higher constitutive NF-kappaB activity and a stronger resistance to H(2)O(2) cytotoxicity. These results indicate that the constitutive activity of NF-kappaB in astrocytes is required for their survival under oxidative stress such as H(2)O(2)."xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.org/dc/terms/identifier | "doi:10.1080/10715760601173010"xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/author | "Choi J.J."xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/author | "Kim W.K."xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/author | "Wu C.F."xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/author | "Kang C.D."xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/author | "Ko K.H."xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/name | "Free Radic Res"xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/pages | "555-562"xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/title | "Hydrogen peroxide induces the death of astrocytes through the down-regulation of the constitutive nuclear factor-kappaB activity."xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/17454138 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17454138 |
| http://purl.uniprot.org/citations/17454138 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17454138 |
| http://purl.uniprot.org/uniprot/F7F7J5#attribution-7660092C80240C5AB2854368A1711D1D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17454138 |
| http://purl.uniprot.org/uniprot/A0A8I6ATQ5#attribution-7660092C80240C5AB2854368A1711D1D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17454138 |
| http://purl.uniprot.org/uniprot/A0A8I5ZMV7#attribution-7660092C80240C5AB2854368A1711D1D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17454138 |
| http://purl.uniprot.org/uniprot/A0A8I6A5H5#attribution-7660092C80240C5AB2854368A1711D1D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17454138 |
| http://purl.uniprot.org/uniprot/A0A2Z5ZBL4#attribution-7660092C80240C5AB2854368A1711D1D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17454138 |
| http://purl.uniprot.org/uniprot/Q7TQN4#attribution-7660092C80240C5AB2854368A1711D1D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17454138 |
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| http://purl.uniprot.org/uniprot/#_A0A8I5ZMV7-mappedCitation-17454138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17454138 |