| http://purl.uniprot.org/citations/17455210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17455210 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of matrix metalloproteinase-13 (MMP-13), involved in bone turnover, is elevated in stretched MC3T3-E1 osteoblast-like cells. Strain-mediated forces impact bone remodeling due in large part to the movement of fluid through the canalicular-lacunar network. The resulting fluid shear stress (FSS) over the surface membranes of bone cells initiates bone remodeling. Although the nuclear events mediating putative FSS-induced changes in osteoblast MMP-13 transcription are unknown, previous studies with bone cells suggest an overlap between osteoblast FSS- and PTH-induced signal response pathways. MMP-13 PTH response is regulated by a 110 bp 5' regulatory region, conserved across the mouse, rat, and human genes, that supports the binding of numerous transcription factors including Runx2, c-fos/c-jun, Ets-1, and nuclear matrix protein 4/cas interacting zinc finger protein (Nmp4/CIZ) a nucleocytoplasmic shuttling trans-acting protein that attenuates PTH-driven transcription. Nmp4/CIZ also binds p130(cas), an adaptor protein implicated in mechanotransduction. Here we sought to determine whether Nmp4/CIZ contributes to FSS-induced changes in MMP-13 transcription. FSS (12 dynes/cm(2), 3-5 h) increased MMP-13 promoter-reporter activity approximately two-fold in MC3T3-E1 osteoblast-like cells attended by a comparable increase in mRNA expression. This was accompanied by a decrease in Nmp4/CIZ binding to its cis-element within the PTH response region, the mutation of which abrogated the MMP-13 response to FSS. Interestingly, FSS enhanced Nmp4/CIZ promoter activity and induced p130(cas) nuclear translocation. We conclude that the PTH regulatory region of MMP-13 also contributes to FSS response and that Nmp4/CIZ plays similar but distinct roles in mediating hormone- and FSS-driven induction of MMP-13 in bone cells."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.21349"xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/author | "Shah R."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/author | "Alvarez M."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/author | "Bidwell J.P."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/author | "Pavalko F.M."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/author | "Robling A.G."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/author | "Charoonpatrapong-Panyayong K."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/author | "Gerard-O'Riley R."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/author | "Templeton E."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/pages | "1202-1213"xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/title | "Nmp4/CIZ contributes to fluid shear stress induced MMP-13 gene induction in osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/17455210 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17455210 |
| http://purl.uniprot.org/citations/17455210 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17455210 |
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| http://purl.uniprot.org/uniprot/#_Q3U1E7-mappedCitation-17455210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17455210 |