| http://purl.uniprot.org/citations/17460044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17460044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17460044 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid-inducible gene I (RIG-I) plays a pivotal role in the regulation of cytokine production induced by pathogens. The RIG-I also augments the production of IFN and other cytokines via an amplification circuit. Because the production of cytokines is closely controlled, up- and down-regulation of RIG-I signaling also needs strict regulation. The mechanism of this regulation, however, remains elusive. Here, we found that RIG-I undergoes proteasomal degradation after conjugation to ubiquitin by RNF125. Further, RNF125 conjugates ubiquitin to MDA5, a family protein of RIG-I as well as IPS-1, which is also a downstream protein of RIG-I signaling that results in suppressing the functions of these proteins. Because RNF125 is enhanced by IFN, these functions constitute a negative regulatory loop circuit for IFN production."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0611551104"xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0611551104"xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Hishiki T."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Hishiki T."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Shimotohno K."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Shimotohno K."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Konishi H."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Konishi H."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Arimoto K."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/author | "Arimoto K."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/pages | "7500-7505"xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/pages | "7500-7505"xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/title | "Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125."xsd:string |
| http://purl.uniprot.org/citations/17460044 | http://purl.uniprot.org/core/title | "Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125."xsd:string |