| http://purl.uniprot.org/citations/17461431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17461431 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundIn type 1 diabetes (T1D), the influence of age at diagnosis and of the IDDM1 and IDDM2 genetic susceptibility loci on the profile of beta-cell autoantibodies has been demonstrated. We studied these associations in a group of 92 patients (children, adolescents and adults, aged 2-62 years) with newly diagnosed T1D.MethodsThe prevalence of the HLA-DQB1*02 and *0302 alleles and of the classes of variable number of tandem repeats (VNTR) of the insulin gene (INS), and of beta-cell autoantibodies (GADA, IA-2A, ICA and IAA) was determined. Statistical analysis was performed using linear and logistic regression models.ResultsThe presence of IAA, IA-2A and ICA, but not of GADA, was negatively associated with age at diagnosis. Younger patients were more likely to have multiple autoantibodies. There was a tendency of a higher prevalence of IAA in patients with the HLA-DQB1*02/0302 genotype or with the DQB1*0302 allele compared to patients lacking these markers. As a novel observation, the INS VNTR I/III genotype was significantly associated with the presence of GADA (OR = 4.79; p = 0.018).ConclusionThe association between the INS VNTR I/III genotype and GADA may suggest that in patients with T1D lacking the INS VNTR I/I genotype, the effect of other susceptibility factors prevails, which promotes the development of autoimmunity to beta-cell antigens other than insulin."xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.org/dc/terms/identifier | "doi:10.1002/dmrr.745"xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/author | "Haller K."xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/author | "Kisand K."xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/author | "Uibo R."xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/author | "Schlosser M."xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/author | "Tillmann V."xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/author | "Rajasalu T."xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/author | "Salur L."xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/name | "Diabetes Metab Res Rev"xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/pages | "567-571"xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/title | "Insulin VNTR I/III genotype is associated with autoantibodies against glutamic acid decarboxylase in newly diagnosed type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/17461431 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17461431 |
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