| http://purl.uniprot.org/citations/17462724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17462724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17462724 | http://www.w3.org/2000/01/rdf-schema#comment | "Using a forward genetics ENU mutagenesis screen for recessive mutations that affect circadian rhythmicity in the mouse, we isolated a long period (approximately 26 hr) circadian mutant named Overtime (Ovtm). Positional cloning and genetic complementation reveal that Ovtm is encoded by the F-box protein FBXL3, a component of the SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligase complex. The Ovtm mutation causes an isoleucine to threonine (I364T) substitution leading to a loss of function in FBXL3, which interacts specifically with the CRYPTOCHROME (CRY) proteins. In Ovtm mice, expression of the PERIOD proteins PER1 and PER2 is reduced; however, the CRY proteins CRY1 and CRY2 are unchanged. The loss of FBXL3 function leads to a stabilization of the CRY proteins, which in turn leads to a global transcriptional repression of the Per and Cry genes. Thus, Fbxl3(Ovtm) defines a molecular link between CRY turnover and CLOCK/BMAL1-dependent circadian transcription to modulate circadian period."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.04.030"xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.04.030"xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Song W."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Song W."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Kumar V."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Kumar V."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Yoo S.H."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Yoo S.H."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Takahashi J.S."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Takahashi J.S."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Siepka S.M."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/author | "Siepka S.M."xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17462724 | http://purl.uniprot.org/core/name | "Cell"xsd:string |