| http://purl.uniprot.org/citations/17462920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17462920 | http://www.w3.org/2000/01/rdf-schema#comment | "Adaptive immune responses by dendritic cells (DCs) are critically controlled by Toll-like receptor (TLR) function. Little is known about modulation of TLR-specific signaling by other pathogen receptors. Here, we have identified a molecular signaling pathway induced by the C-type lectin DC-SIGN that modulates TLR signaling at the level of the transcription factor NF-kappaB. We demonstrated that pathogens trigger DC-SIGN on human DCs to activate the serine and threonine kinase Raf-1, which subsequently leads to acetylation of the NF-kappaB subunit p65, but only after TLR-induced activation of NF-kappaB. Acetylation of p65 both prolonged and increased IL10 transcription to enhance anti-inflammatory cytokine responses. We demonstrated that different pathogens such as Mycobacterium tuberculosis, M. leprae, Candida albicans, measles virus, and human immunodeficiency virus-1 interacted with DC-SIGN to activate the Raf-1-acetylation-dependent signaling pathway to modulate signaling by different TLRs. Thus, this pathway is involved in regulation of adaptive immunity by DCs to bacterial, fungal, and viral pathogens."xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2007.03.012"xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/author | "Geijtenbeek T.B."xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/author | "van Kooyk Y."xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/author | "den Dunnen J."xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/author | "Gringhuis S.I."xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/author | "Litjens M."xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/author | "van Het Hof B."xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/pages | "605-616"xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/title | "C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB."xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/17462920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17462920 |
| http://purl.uniprot.org/citations/17462920 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17462920 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PIN7-mappedCitation-17462920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17462920 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PJU2-mappedCitation-17462920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17462920 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PJU9-mappedCitation-17462920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17462920 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PMS7-mappedCitation-17462920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17462920 |
| http://purl.uniprot.org/uniprot/#_A0A0H4Q180-mappedCitation-17462920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17462920 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4L5-mappedCitation-17462920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17462920 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z559-mappedCitation-17462920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17462920 |
| http://purl.uniprot.org/uniprot/#_B2R907-mappedCitation-17462920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17462920 |
| http://purl.uniprot.org/uniprot/#_B4E2A8-mappedCitation-17462920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17462920 |