| http://purl.uniprot.org/citations/17462921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17462921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17462921 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytomegaloviruses are known to encode several gene products that function to subvert MHC-dependent immune recognition. Here we characterize a rat cytomegalovirus (RCMV) C-type lectin-like (RCTL) gene product with homology to the Clr ligands for the NKR-P1 receptors. RCMV infection rapidly extinguished host Clr-b expression, thereby sensitizing infected cells to killing by natural killer (NK) cells. However, the RCTL protein functioned as a decoy ligand to protect infected cells from NK killing via direct interaction with the NKR-P1B inhibitory receptor. In vivo, an RCTL mutant virus displayed diminished virulence in an NK-dependent and strain-specific manner, suggesting that host NKR-P1 polymorphisms have evolved to avert the viral decoy mechanism while maintaining Clr-b recognition to preserve self tolerance. These findings reveal a unique strategy adopted by cytomegaloviruses to evade MHC-independent self-nonself discrimination. The existence of lectin-like genes in several poxviruses suggests that this may represent a common theme for viral evasion of innate immunity."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2007.03.013"xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2007.03.013"xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Voigt S."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Voigt S."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Chou W."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Chou W."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Ettinger J."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Ettinger J."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Carlyle J.R."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Carlyle J.R."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Fine J.H."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Fine J.H."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Mesci A."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/author | "Mesci A."xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/pages | "617-627"xsd:string |
| http://purl.uniprot.org/citations/17462921 | http://purl.uniprot.org/core/pages | "617-627"xsd:string |