| http://purl.uniprot.org/citations/17463246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17463246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17463246 | http://www.w3.org/2000/01/rdf-schema#comment | "New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1142358"xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1142358"xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Altshuler D."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Altshuler D."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Ardlie K."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Ardlie K."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Carlson J."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Carlson J."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Daly M.J."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Daly M.J."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Nilsson P."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Nilsson P."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Sougnez C."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Sougnez C."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Meyer J."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Meyer J."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Ricke D."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Ricke D."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Camarata J."xsd:string |
| http://purl.uniprot.org/citations/17463246 | http://purl.uniprot.org/core/author | "Camarata J."xsd:string |