| http://purl.uniprot.org/citations/17468107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17468107 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously demonstrated that DNA damage leads to stabilization and accumulation of Che-1, an RNA polymerase II-binding protein that plays an important role in transcriptional activation of p53 and in maintenance of the G(2)/M checkpoint. Here we show that Che-1 is down-regulated during the apoptotic process. We found that the E3 ligase HMD2 physically and functionally interacts with Che-1 and promotes its degradation via the ubiquitin-dependent proteasomal system. Furthermore, we found that in response to apoptotic stimuli Che-1 interacts with the peptidyl-prolyl isomerase Pin1 and that conformational changes generated by Pin1 are required for Che-1/HDM2 interaction. Notably, a Che-1 mutant lacking the capacity to bind Pin1 exhibits an increased half-life and this correlates with a diminished apoptosis in response to genotoxic stress. Our results establish Che-1 as a new Pin1 and HDM2 target and confirm its important role in the cellular response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m610282200"xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/author | "Bruno T."xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/author | "De Nicola F."xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/author | "Di Padova M."xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/author | "Fanciulli M."xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/author | "Floridi A."xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/author | "Iezzi S."xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/author | "Passananti C."xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/author | "Del Sal G."xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/pages | "19685-19691"xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/title | "The prolyl isomerase Pin1 affects Che-1 stability in response to apoptotic DNA damage."xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17468107 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17468107 |
| http://purl.uniprot.org/citations/17468107 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17468107 |
| http://purl.uniprot.org/uniprot/#_B3KUM4-mappedCitation-17468107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17468107 |
| http://purl.uniprot.org/uniprot/#_P23804-mappedCitation-17468107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17468107 |
| http://purl.uniprot.org/uniprot/#_Q13526-mappedCitation-17468107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17468107 |
| http://purl.uniprot.org/uniprot/#_Q2L9A9-mappedCitation-17468107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17468107 |
| http://purl.uniprot.org/uniprot/#_Q3TVL4-mappedCitation-17468107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17468107 |
| http://purl.uniprot.org/uniprot/#_Q569X0-mappedCitation-17468107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17468107 |
| http://purl.uniprot.org/uniprot/#_Q3UTI7-mappedCitation-17468107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17468107 |