Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/17469103http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17469103http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Anti-cyclic citrullinated peptide (anti-CCP) antibodies are rheumatoid arthritis (RA)-specific serologic markers. RA susceptibility has been associated with HLA-DRB1 shared epitope (SE) alleles and single-nucleotide polymorphism (SNP) haplotypes in the peptidyl arginine deiminase 4 gene (PADI4). This study was undertaken to determine whether anti-CCP levels are associated with PADI4 haplotypes and/or SE alleles in Korean patients with RA.

Methods

Three nonsynonymous SNPs in PADI4 (padi4_89, padi4_90, and padi4_92) and SE alleles were genotyped, and serum anti-CCP levels were measured, in 311 patients with nonerosive or erosive RA. The relationships between anti-CCP levels and PADI4 haplotypes and/or SE alleles were analyzed statistically.

Results

Anti-CCP levels were significantly higher in patients carrying the PADI4 RA risk haplotype than in patients who did not have the risk haplotype, among anti-CCP-positive patients with RA with a disease duration of or=141 months (P = 0.0037) and among those who had erosive RA (P = 0.000098), but not among patients who had a shorter disease duration or those who had nonerosive RA.

Conclusion

The PADI4 RA risk haplotype is associated with increased anti-CCP levels in RA patients with disease of short duration, and PADI4 may play a role in early RA. In contrast, SE alleles are associated with increased anti-CCP levels in RA patients with very longstanding disease and in patients with erosive RA, suggesting that SE alleles play a role in very late RA."xsd:string
http://purl.uniprot.org/citations/17469103http://purl.org/dc/terms/identifier"doi:10.1002/art.22570"xsd:string
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/author"Cha S."xsd:string
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/author"Kang C."xsd:string
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/author"Bae S.C."xsd:string
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/author"Kang C.P."xsd:string
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/author"Choi C.B."xsd:string
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/author"Han T.U."xsd:string
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/name"Arthritis Rheum"xsd:string
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/pages"1454-1463"xsd:string
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/title"Association of anti-cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis."xsd:string
http://purl.uniprot.org/citations/17469103http://purl.uniprot.org/core/volume"56"xsd:string
http://purl.uniprot.org/citations/17469103http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17469103
http://purl.uniprot.org/citations/17469103http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17469103
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-17469103http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17469103
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-17469103http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17469103
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-17469103http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17469103
http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-17469103http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17469103
http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-17469103http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17469103
http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-17469103http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17469103
http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-17469103http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17469103
http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-17469103http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17469103
http://purl.uniprot.org/uniprot/#_A0A141AZI4-mappedCitation-17469103http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17469103
▶