| http://purl.uniprot.org/citations/17470806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17470806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17470806 | http://www.w3.org/2000/01/rdf-schema#comment | "The pituitary adenylate cyclase-activating polypeptide (PACAP) receptor is a class II G protein-coupled receptor that contributes to many different cellular functions including neurotransmission, neuronal survival, and synaptic plasticity. The solution structure of the potent antagonist PACAP (residues 6'-38') complexed to the N-terminal extracellular (EC) domain of the human splice variant hPAC1-R-short (hPAC1-R(S)) was determined by NMR. The PACAP peptide adopts a helical conformation when bound to hPAC1-R(S) with a bend at residue A18' and makes extensive hydrophobic and electrostatic interactions along the exposed beta-sheet and interconnecting loops of the N-terminal EC domain. Mutagenesis data on both the peptide and the receptor delineate the critical interactions between the C terminus of the peptide and the C terminus of the EC domain that define the high affinity and specificity of hormone binding to hPAC1-R(S). These results present a structural basis for hPAC1-R(S) selectivity for PACAP versus the vasoactive intestinal peptide and also differentiate PACAP residues involved in binding to the N-terminal extracellular domain versus other parts of the full-length hPAC1-R(S) receptor. The structural, mutational, and binding data are consistent with a model for peptide binding in which the C terminus of the peptide hormone interacts almost exclusively with the N-terminal EC domain, whereas the central region makes contacts to both the N-terminal and other extracellular parts of the receptor, ultimately positioning the N terminus of the peptide to contact the transmembrane region and result in receptor activation."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0611397104"xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0611397104"xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Sun C."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Sun C."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Olejniczak E.T."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Olejniczak E.T."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Song D."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Song D."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Walter K.A."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Walter K.A."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Lake M.R."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Lake M.R."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Hajduk P.J."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Hajduk P.J."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Pereda-Lopez A."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Pereda-Lopez A."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Davis-Taber R.A."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Davis-Taber R.A."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Scott V.E."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Scott V.E."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Barrett L.W."xsd:string |
| http://purl.uniprot.org/citations/17470806 | http://purl.uniprot.org/core/author | "Barrett L.W."xsd:string |