| http://purl.uniprot.org/citations/17475216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17475216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17475216 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendroaspis natriuretic peptide (DNP) is a newly-described natriuretic peptide which lowers blood pressure via vasodilation. The natriuretic peptide clearance receptor (NPR-C) removes natriuretic peptides from the circulation, but whether DNP interacts with human NPR-C directly is unknown. The purpose of this study was to test the hypothesis that DNP binds to NPR-C. ANP, BNP, CNP, and the NPR-C ligands AP-811 and cANP(4-23) displaced [(125)I]-ANP from NPR-C with pM-to-nM K(i) values. DNP displaced [(125)I]-ANP from NPR-C with nM potency, which represents the first direct demonstration of binding of DNP to human NPR-C. DNP showed high pM affinity for the GC-A receptor and no affinity for GC-B (K(i)>1000 nM). DNP was nearly 10-fold more potent than ANP at stimulating cGMP production in GC-A expressing cells. Blockade of NPR-C might represent a novel therapeutic approach in augmenting the known beneficial actions of DNP in cardiovascular diseases such as hypertension and heart failure."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.04.079"xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.04.079"xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Lu Q."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Lu Q."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Ao Z."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Ao Z."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Graham T."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Graham T."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Aiyar N."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Aiyar N."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Douglas S.A."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Douglas S.A."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Payne L."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Payne L."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Elshourbagy N."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Elshourbagy N."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Johns D.G."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Johns D.G."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Heidrich B.J."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Heidrich B.J."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Hunsberger G.E."xsd:string |
| http://purl.uniprot.org/citations/17475216 | http://purl.uniprot.org/core/author | "Hunsberger G.E."xsd:string |