| http://purl.uniprot.org/citations/17475832 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17475832 | http://www.w3.org/2000/01/rdf-schema#comment | "B and T lymphocyte attenuator (BTLA; CD272) can deliver inhibitory signals to B and T cells upon binding its ligand herpesvirus entry mediator. Because CD28, CTLA-4, programmed death-1, and ICOS regulate the development of acute graft-vs-host disease (GVHD), we wished to assess if BTLA also played a role in this T cell-mediated response. In the nonirradiated parental-into-F1 model of acute GVHD, BTLA+/+ and BTLA-/-donor lymphocytes showed equivalent engraftment and expansion during the first week of the alloresponse. Unexpectedly, BTLA-/-donor T cells failed to sustain GVHD, showing a decline in surviving donor cell numbers beginning at day 9 and greatly reduced by day 11. Similarly, inhibition of BTLA-herpesvirus entry mediator engagement by in vivo administration of a blocking anti-BTLA Ab also caused reduced survival of donor cells. Microarray analysis revealed several genes that were differentially expressed by BTLA-/- and BTLA+/+ donor CD4+ T cells preceding the decline in BTLA-/-donor T cells. Several genes influencing Th cell polarization were differentially expressed by BTLA+/+ and BTLA-/-donor cells. Additionally, the re-expression of the IL-7Ralpha subunit that occurs in BTLA+/+ donor cells after 1 wk of in vivo allostimulation was not observed in BTLA-/- donor CD4+ cells. The striking loss of BTLA-/-T cells in this model indicates a role for BTLA activity in sustaining CD4+ T cell survival under the conditions of chronic stimulation in the nonirradiated parental-into-F1 GVHD."xsd:string |
| http://purl.uniprot.org/citations/17475832 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.10.6073"xsd:string |
| http://purl.uniprot.org/citations/17475832 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/17475832 | http://purl.uniprot.org/core/author | "Hurchla M.A."xsd:string |
| http://purl.uniprot.org/citations/17475832 | http://purl.uniprot.org/core/author | "Sedy J.R."xsd:string |
| http://purl.uniprot.org/citations/17475832 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17475832 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17475832 | http://purl.uniprot.org/core/pages | "6073-6082"xsd:string |
| http://purl.uniprot.org/citations/17475832 | http://purl.uniprot.org/core/title | "Unexpected role of B and T lymphocyte attenuator in sustaining cell survival during chronic allostimulation."xsd:string |
| http://purl.uniprot.org/citations/17475832 | http://purl.uniprot.org/core/volume | "178"xsd:string |
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