| http://purl.uniprot.org/citations/17475851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17475851 | http://www.w3.org/2000/01/rdf-schema#comment | "The absence of B7-2-mediated costimulation protects NOD mice from the development of diabetes. Although the effects of B7-2 on T cell priming are well known, its impact on the function of APCs is not fully elucidated. We tested APC function and survival in mice lacking B7-2. A significant reduction in the phagocytic ability was observed in both splenic and pancreatic lymph node-associated dendritic cells (DCs) in B7-2 knockout (KO) mice. DCs from B7-2KO mice exhibited enhanced susceptibility to death, which was reflected by their reduced total cell numbers. Phenotypic analysis of APCs in B7-2KO mice revealed a significantly decreased proportion of CD8alpha+CD205+ DCs. Interestingly, an enhanced proportion of B7-H1+ and B7-DC+ DCs were observed in B7-2KO mice. Lastly, we found that B7-2 deficiency significantly diminished the PKC-epsilon response in APCs upon CD28-Ig stimulation. In conclusion our data suggests that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival."xsd:string |
| http://purl.uniprot.org/citations/17475851 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.10.6236"xsd:string |
| http://purl.uniprot.org/citations/17475851 | http://purl.uniprot.org/core/author | "Sarvetnick N."xsd:string |
| http://purl.uniprot.org/citations/17475851 | http://purl.uniprot.org/core/author | "Yadav D."xsd:string |
| http://purl.uniprot.org/citations/17475851 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17475851 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17475851 | http://purl.uniprot.org/core/pages | "6236-6241"xsd:string |
| http://purl.uniprot.org/citations/17475851 | http://purl.uniprot.org/core/title | "B7-2 regulates survival, phenotype, and function of APCs."xsd:string |
| http://purl.uniprot.org/citations/17475851 | http://purl.uniprot.org/core/volume | "178"xsd:string |
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