| http://purl.uniprot.org/citations/17475863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17475863 | http://www.w3.org/2000/01/rdf-schema#comment | "Production of IFN-gamma by CD4 T cells is generally thought to be mediated by TCR triggering, however, Ag-nonspecific activation of effector CD8 T cells has been reported in infection models. In this study, we demonstrate that Ag-experienced CD4 T cells in the spleen of Salmonella-infected mice acquire the capacity to rapidly secrete IFN-gamma in response to stimulation with bacterial lysate or LPS. This innate responsiveness of T cells was transient and most apparent during, and immediately following, active Salmonella infection. Furthermore, innate T cell production of IFN-gamma in response to bacterial lysate or LPS was Ag independent and could be induced in Listeria-infected mice and in the absence of MHC class II expression. IL-18 was required for maximal innate responsiveness of CD4 T cells in Salmonella-infected mice and for optimal bacterial clearance in vivo. These data demonstrate that CD4 T cells acquire the capacity to respond to innate stimuli during active bacterial infection, a process that may contribute significantly to amplifying effector responses in vivo."xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.10.6342"xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/author | "Srinivasan A."xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/author | "Lefrancois L."xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/author | "Sandau M.M."xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/author | "Jarcho M."xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/author | "McSorley S.J."xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/author | "Salazar-Gonzalez R.M."xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/pages | "6342-6349"xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/title | "Innate immune activation of CD4 T cells in salmonella-infected mice is dependent on IL-18."xsd:string |
| http://purl.uniprot.org/citations/17475863 | http://purl.uniprot.org/core/volume | "178"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YWA3-mappedCitation-17475863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475863 |
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