http://purl.uniprot.org/citations/17475873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/17475873 | http://www.w3.org/2000/01/rdf-schema#comment | "To assess the combined role of G-CSF, GM-CSF, and M-CSF in myeloid cell production, mice deficient in all three myeloid CSFs were generated (G-/-GM-/-M-/- mice). G-/-GM-/-M-/-mice share characteristics found in mice lacking individual cytokines: they are toothless and osteopetrotic and furthermore acquire alveolar proteinosis that is more severe than that found in either GM-/- or G-/-GM-/- mice. G-/-GM-/-M-/-mice have a significantly reduced lifespan, which is prolonged by antibiotic administration, suggesting compromised ability to control bacterial infection. G-/-GM-/-M-/-mice have circulating neutrophils and monocytes, albeit at significantly reduced numbers compared with wild-type mice, but surprisingly, have more circulating monocytes than M-/- mice and more circulating neutrophils than G-/-GM-/-mice. Due to severe osteopetrosis, G-/-GM-/-M-/-mice show diminished numbers of myeloid cells, myeloid progenitors, and B lymphocytes in the bone marrow, but have significantly enhanced compensatory splenic hemopoiesis. Although G-/-GM-/-M-/-mice have a profound deficiency of myeloid cells in the resting peritoneal cavity, the animals mount a moderate cellular response in a model of sterile peritonitis. These data establish that in the absence of G-CSF, GM-CSF, and M-CSF, additional growth factor(s) can stimulate myelopoiesis and acute inflammatory responses."xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.10.6435"xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/author | "Dunn A.R."xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/author | "Burgess A.W."xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/author | "Hibbs M.L."xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/author | "Kountouri N."xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/author | "Quilici C."xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/author | "Armes J.E."xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/author | "Seymour J.F."xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/pages | "6435-6443"xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/title | "Mice lacking three myeloid colony-stimulating factors (G-CSF, GM-CSF, and M-CSF) still produce macrophages and granulocytes and mount an inflammatory response in a sterile model of peritonitis."xsd:string |
http://purl.uniprot.org/citations/17475873 | http://purl.uniprot.org/core/volume | "178"xsd:string |
http://purl.uniprot.org/citations/17475873 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17475873 |
http://purl.uniprot.org/citations/17475873 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17475873 |
http://purl.uniprot.org/uniprot/#_Q0VB73-mappedCitation-17475873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475873 |
http://purl.uniprot.org/uniprot/#_D3YTW1-mappedCitation-17475873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475873 |
http://purl.uniprot.org/uniprot/#_D3Z090-mappedCitation-17475873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475873 |
http://purl.uniprot.org/uniprot/#_P09920-mappedCitation-17475873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475873 |
http://purl.uniprot.org/uniprot/#_F6RNW8-mappedCitation-17475873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475873 |
http://purl.uniprot.org/uniprot/#_Q14AD9-mappedCitation-17475873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475873 |
http://purl.uniprot.org/uniprot/#_Q3UM22-mappedCitation-17475873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475873 |
http://purl.uniprot.org/uniprot/#_P07141-mappedCitation-17475873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475873 |