| http://purl.uniprot.org/citations/17475883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17475883 | http://www.w3.org/2000/01/rdf-schema#comment | "Most of our knowledge of the antigenic repertoire of autoreactive B lymphocytes in type 1 diabetes (T1D) comes from studies on the antigenic specificity of both circulating islet-reactive autoantibodies and peripheral B lymphocyte hybridomas generated from human blood or rodent spleen. In a recent study, we generated hybridoma cell lines of infiltrating B lymphocytes from different mouse strains developing insulitis, but with different degrees of susceptibility to T1D, to characterize the antigenic specificity of islet-infiltrating B lymphocytes during progression of the disease. We found that many hybridomas produced mAbs restricted to the peripheral nervous system (PNS), thus indicating an active B lymphocyte response against PNS elements in the pancreatic islet during disease development. The aim of this study was to identify the autoantigen recognized by these anti-PNS mAbs. Our results showed that peripherin is the autoantigen recognized by all anti-PNS mAbs, and, therefore, a relevant neuroendocrine autoantigen targeted by islet-infiltrating B lymphocytes. Moreover, we discovered that the immune dominant epitope of this B lymphocyte immune response is found at the C-terminal end of Per58 and Per61 isoforms. In conclusion, our study strongly suggests that peripherin is a major autoantigen targeted during T1D development and poses a new question on why peripherin-specific B lymphocytes are mainly attracted to the islet during disease."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.10.6533"xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Alba A."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Bruno R."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Carrillo J."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Pujol-Borrell R."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Estanyol J.M."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Planas R."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Puertas M.C."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Verdaguer J."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Pastor X."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Vives-Pi M."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/author | "Ampudia R.M."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/pages | "6533-6539"xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/title | "Peripherin is a relevant neuroendocrine autoantigen recognized by islet-infiltrating B lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/17475883 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17475883 |
| http://purl.uniprot.org/citations/17475883 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17475883 |
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| http://purl.uniprot.org/uniprot/#_A0A2R8W6R6-mappedCitation-17475883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475883 |
| http://purl.uniprot.org/uniprot/#_G3X981-mappedCitation-17475883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475883 |
| http://purl.uniprot.org/uniprot/#_G5E846-mappedCitation-17475883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17475883 |