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| http://purl.uniprot.org/citations/17478680 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptic vesicles loaded with neurotransmitters are exocytosed in a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent manner after presynaptic depolarization induces calcium ion (Ca2+) influx. The Ca2+ sensor required for fast fusion is synaptotagmin-1. The activation energy of bilayer-bilayer fusion is very high (approximately 40 k(B)T). We found that, in response to Ca2+ binding, synaptotagmin-1 could promote SNARE-mediated fusion by lowering this activation barrier by inducing high positive curvature in target membranes on C2-domain membrane insertion. Thus, synaptotagmin-1 triggers the fusion of docked vesicles by local Ca2+-dependent buckling of the plasma membrane together with the zippering of SNAREs. This mechanism may be widely used in membrane fusion."xsd:string |
| http://purl.uniprot.org/citations/17478680 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1142614"xsd:string |
| http://purl.uniprot.org/citations/17478680 | http://purl.uniprot.org/core/author | "Martens S."xsd:string |
| http://purl.uniprot.org/citations/17478680 | http://purl.uniprot.org/core/author | "McMahon H.T."xsd:string |
| http://purl.uniprot.org/citations/17478680 | http://purl.uniprot.org/core/author | "Kozlov M.M."xsd:string |
| http://purl.uniprot.org/citations/17478680 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17478680 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/17478680 | http://purl.uniprot.org/core/pages | "1205-1208"xsd:string |
| http://purl.uniprot.org/citations/17478680 | http://purl.uniprot.org/core/title | "How synaptotagmin promotes membrane fusion."xsd:string |
| http://purl.uniprot.org/citations/17478680 | http://purl.uniprot.org/core/volume | "316"xsd:string |
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