| http://purl.uniprot.org/citations/17479107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17479107 | http://www.w3.org/2000/01/rdf-schema#comment | "The death ligand Apo2L/TRAIL (Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand) eradicates many tumor types while sparing most normal tissues. However, some tumors are resistant to TRAIL. We therefore determined if TRAIL cooperates with cytosine deaminase/5-fluorocytosine (CD/5-FC) gene therapy and investigated the mechanisms involved. Transfection of human LAN-5 neuroblastoma cells with CD rendered the cells (LAN-5-CD) sensitive to 5-FC-induced, caspase-dependent apoptosis. Mediated by caspase-3, CD/5-FC and TRAIL cooperated to induce apoptosis in these TRAIL-resistant cells and to cleave X-linked inhibitor of apoptosis protein (XIAP). In established LAN-5-CD tumors growing subcutaneously in mice, intratumorally applied TRAIL did not decrease tumor growth and systemically administered 5-FC only attenuated tumor growth. In contrast, 5-FC together with TRAIL dramatically decreased tumor growth and eradicated a tumor. Assuming sufficient gene transfer of CD in situ, CD/5-FC with TRAIL may be useful for the therapy of tumors resistant to TRAIL."xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cgt.7701051"xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/author | "Wei J."xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/author | "Zeller S."xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/author | "Debatin K.M."xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/author | "Wahl J."xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/author | "Fitze G."xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/author | "Beltinger C."xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/author | "Jarmy G."xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/author | "Knauss H."xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/name | "Cancer Gene Ther"xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/pages | "640-651"xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/title | "Cytosine deaminase/5-fluorocytosine gene therapy and Apo2L/TRAIL cooperate to kill TRAIL-resistant tumor cells."xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/17479107 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17479107 |
| http://purl.uniprot.org/citations/17479107 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17479107 |
| http://purl.uniprot.org/uniprot/#_A0A0U5EM55-mappedCitation-17479107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17479107 |
| http://purl.uniprot.org/uniprot/#_P50591-mappedCitation-17479107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17479107 |
| http://purl.uniprot.org/uniprot/#_P32320-mappedCitation-17479107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17479107 |
| http://purl.uniprot.org/uniprot/#_Q6GV32-mappedCitation-17479107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17479107 |
| http://purl.uniprot.org/uniprot/#_Q71UE9-mappedCitation-17479107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17479107 |
| http://purl.uniprot.org/uniprot/#_Q6IBA9-mappedCitation-17479107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17479107 |
| http://purl.uniprot.org/uniprot/#_Q6JSD9-mappedCitation-17479107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17479107 |