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| http://purl.uniprot.org/citations/17481395 | http://www.w3.org/2000/01/rdf-schema#comment | "Alternative splicing of the Drosophila gene Dscam results in up to 38,016 different receptor isoforms proposed to interact by isoform-specific homophilic binding. We report that Dscam controls cell-intrinsic aspects of dendrite guidance in all four classes of dendrite arborization (da) neurons. Loss of Dscam in single neurons causes a strong increase in self-crossing. Restriction of dendritic fields of neighboring class III neurons appeared intact in mutant neurons, suggesting that dendritic self-avoidance, but not heteroneuronal tiling, may depend on Dscam. Overexpression of the same Dscam isoforms in two da neurons with overlapping dendritic fields forced a spatial segregation of the two fields, supporting the model that dendritic branches of da neurons use isoform-specific homophilic interactions to ensure minimal overlap. Homophilic binding of the highly diverse extracellular domains of Dscam may therefore limit the use of the same "core" repulsion mechanism to cell-intrinsic interactions without interfering with heteroneuronal interactions."xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2007.04.013"xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/author | "Kondo M."xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/author | "Uemura T."xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/author | "Tsubouchi A."xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/author | "Hughes M.E."xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/author | "Schmucker D."xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/author | "Baumer P."xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/author | "Bortnick R."xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/pages | "417-427"xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/title | "Homophilic Dscam interactions control complex dendrite morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/17481395 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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