| http://purl.uniprot.org/citations/17482543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17482543 | http://www.w3.org/2000/01/rdf-schema#comment | "Although NAD(+) biosynthesis is required for Sir2 functions and replicative lifespan in yeast, alterations in NAD(+) precursors have been reported to accelerate aging but not to extend lifespan. In eukaryotes, nicotinamide riboside is a newly discovered NAD(+) precursor that is converted to nicotinamide mononucleotide by specific nicotinamide riboside kinases, Nrk1 and Nrk2. In this study, we discovered that exogenous nicotinamide riboside promotes Sir2-dependent repression of recombination, improves gene silencing, and extends lifespan without calorie restriction. The mechanism of action of nicotinamide riboside is totally dependent on increased net NAD(+) synthesis through two pathways, the Nrk1 pathway and the Urh1/Pnp1/Meu1 pathway, which is Nrk1 independent. Additionally, the two nicotinamide riboside salvage pathways contribute to NAD(+) metabolism in the absence of nicotinamide-riboside supplementation. Thus, like calorie restriction in the mouse, nicotinamide riboside elevates NAD(+) and increases Sir2 function."xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.03.024"xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/author | "Belenky P."xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/author | "Smith J.S."xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/author | "Brenner C."xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/author | "Bogan K.L."xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/author | "McClure J.M."xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/author | "Racette F.G."xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/pages | "473-484"xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/title | "Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+."xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/17482543 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17482543 |
| http://purl.uniprot.org/citations/17482543 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17482543 |
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