| http://purl.uniprot.org/citations/17482545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17482545 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-adrenergic receptors (beta-ARs), prototypic G-protein-coupled receptors (GPCRs), play a critical role in regulating numerous physiological processes. The GPCR kinases (GRKs) curtail G-protein signaling and target receptors for internalization. Nitric oxide (NO) and/or S-nitrosothiols (SNOs) can prevent the loss of beta-AR signaling in vivo, but the molecular details are unknown. Here we show in mice that SNOs increase beta-AR expression and prevent agonist-stimulated receptor downregulation; and in cells, SNOs decrease GRK2-mediated beta-AR phosphorylation and subsequent recruitment of beta-arrestin to the receptor, resulting in the attenuation of receptor desensitization and internalization. In both cells and tissues, GRK2 is S-nitrosylated by SNOs as well as by NO synthases, and GRK2 S-nitrosylation increases following stimulation of multiple GPCRs with agonists. Cys340 of GRK2 is identified as a principal locus of inhibition by S-nitrosylation. Our studies thus reveal a central molecular mechanism through which GPCR signaling is regulated."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.02.046"xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Ozawa K."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Nelson C.D."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Matsumoto A."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Daaka Y."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Stamler J.S."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Whalen E.J."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Koch W.J."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Violin J.D."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Rockman H.A."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Foster M.W."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Keys J.R."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Que L.G."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/author | "Benhar M."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/pages | "511-522"xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/title | "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2."xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/17482545 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17482545 |
| http://purl.uniprot.org/citations/17482545 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17482545 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z392-mappedCitation-17482545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17482545 |