http://purl.uniprot.org/citations/17484618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/17484618 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundWe examined the influence of apolipoprotein E (apoE) polymorphism on longitudinal changes in serum lipids by following the subjects participating in The Cardiovascular Risk in Young Finns Study over a 21-year period.MethodsSerum lipids were determined in randomly selected Finnish children and adolescents in 1980 and the subjects were re-examined in 1983, 1986 and after 21 years in 2001. ApoE polymorphism was determined in 1736 participants, and serum lipid values and apoE phenotypes were available for 1233 subjects.ResultsApoE phenotype-related differences in serum total and low-density lipoprotein (LDL)-cholesterol were maintained throughout the 21-year follow-up from childhood to adulthood, i.e., the apoE epsilon2 allele was consistently associated with lower and the epsilon4 allele with higher total and LDL-cholesterol (p<0.001 for all). In adulthood, there was also a significant apoE phenotype-related difference in high-density lipoprotein (HDL)-cholesterol (p=0.007), and the epsilon2 allele was associated with higher and the epsilon4 allele with lower apoA-I and HDL-cholesterol. In addition, apoB increased in the phenotype order E3/2ConclusionsApoE polymorphism is associated with lipid levels at different ages and affects the longitudinal change in LDL-cholesterol from childhood to adulthood."xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.org/dc/terms/identifier | "doi:10.1515/cclm.2007.116"xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/author | "Lehtimaki T."xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/author | "Kahonen M."xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/author | "Raitakari O.T."xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/author | "Viikari J."xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/author | "Marniemi J."xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/author | "Hutri-Kahonen N."xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/author | "Gronroos P."xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/name | "Clin Chem Lab Med"xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/pages | "592-598"xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/title | "Influence of apolipoprotein E polymorphism on serum lipid and lipoprotein changes: a 21-year follow-up study from childhood to adulthood. The Cardiovascular Risk in Young Finns Study."xsd:string |
http://purl.uniprot.org/citations/17484618 | http://purl.uniprot.org/core/volume | "45"xsd:string |
http://purl.uniprot.org/citations/17484618 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17484618 |
http://purl.uniprot.org/citations/17484618 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17484618 |
http://purl.uniprot.org/uniprot/#_A0A0S2Z3B1-mappedCitation-17484618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17484618 |
http://purl.uniprot.org/uniprot/#_A0A0S2Z3V0-mappedCitation-17484618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17484618 |
http://purl.uniprot.org/uniprot/#_A0A0S2Z3D5-mappedCitation-17484618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17484618 |
http://purl.uniprot.org/uniprot/#_A0A0S2Z3J5-mappedCitation-17484618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17484618 |
http://purl.uniprot.org/uniprot/#_A0A346DBY2-mappedCitation-17484618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17484618 |
http://purl.uniprot.org/uniprot/#_D9ZB55-mappedCitation-17484618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17484618 |
http://purl.uniprot.org/uniprot/#_E1A689-mappedCitation-17484618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17484618 |
http://purl.uniprot.org/uniprot/#_A8K479-mappedCitation-17484618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17484618 |