| http://purl.uniprot.org/citations/17485464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17485464 | http://www.w3.org/2000/01/rdf-schema#comment | "Postmenopausal osteoporosis and rheumatoid joint destruction result from increased osteoclast formation and bone resorption induced by receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor (TNF). Osteoclast formation induced by these cytokines requires NF-kappaB p50 and p52, c-Fos, and NFATc1 expression in osteoclast precursors. c-Fos induces NFATc1, but the relationship between NF-kappaB and these other transcription factors in osteoclastogenesis remains poorly understood. We report that RANKL and TNF can induce osteoclast formation directly from NF-kappaB p50/p52 double knockout (dKO) osteoclast precursors when either c-Fos or NFATc1 is expressed. RANKL- or TNF-induced c-Fos up-regulation and activation are abolished in dKO cells and in wild-type cells treated with an NF-kappaB inhibitor. c-Fos expression requires concomitant RANKL or TNF treatment to induce NFATc1 activation in the dKO cells. Furthermore, c-Fos expression increases the number and resorptive capacity of wild-type osteoclasts induced by TNF in vitro. We conclude that NF-kappaB controls early osteoclast differentiation from precursors induced directly by RANKL and TNF, leading to activation of c-Fos followed by NFATc1. Inhibition of NF-kappaB should prevent RANKL- and TNF-induced bone resorption."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m610701200"xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Matsuo K."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Yao Z."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Xing L."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Yamashita T."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Wagner E.F."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Schwarz E.M."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Takeshita S."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Boyce B.F."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/author | "Badell I.R."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/pages | "18245-18253"xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/title | "NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1."xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17485464 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17485464 |
| http://purl.uniprot.org/citations/17485464 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17485464 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-17485464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17485464 |
| http://purl.uniprot.org/uniprot/#_Q0X0E6-mappedCitation-17485464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17485464 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-17485464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17485464 |