| http://purl.uniprot.org/citations/17485511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17485511 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 receptor-associated kinase 4 (IRAK-4) was reported to be essential for the Toll-like receptor (TLR)- and T cell receptor (TCR)-mediated signaling leading to the activation of nuclear factor kappaB (NF-kappaB). However, the importance of kinase activity of IRAK family members is unclear. In this study, we investigated the functional role of IRAK-4 activity in vivo by generating mice carrying a knockin mutation (KK213AA) that abrogates its kinase activity. IRAK-4(KN/KN) mice were highly resistant to TLR-induced shock response. The cytokine production in response to TLR ligands was severely impaired in IRAK-4(KN/KN) as well as IRAK-4(-/-) macrophages. The IRAK-4 activity was essential for the activation of signaling pathways leading to mitogen-activated protein kinases. TLR-induced IRAK-4/IRAK-1-dependent and -independent pathways were involved in early induction of NF-kappaB-regulated genes in response to TLR ligands such as tumor necrosis factor alpha and IkappaBzeta. In contrast to a previous paper (Suzuki, N., S. Suzuki, D.G. Millar, M. Unno, H. Hara, T. Calzascia, S. Yamasaki, T. Yokosuka, N.J. Chen, A.R. Elford, et al. 2006. Science. 311:1927-1932), the TCR signaling was not impaired in IRAK-4(-/-) and IRAK-4(KN/KN) mice. Thus, the kinase activity of IRAK-4 is essential for the regulation of TLR-mediated innate immune responses."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20061523"xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/author | "Matsui K."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/author | "Jung A."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/author | "Uematsu S."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/author | "Kawagoe T."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/pages | "1013-1024"xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/title | "Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling."xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/17485511 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17485511 |
| http://purl.uniprot.org/citations/17485511 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17485511 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-17485511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17485511 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-17485511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17485511 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-17485511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17485511 |
| http://purl.uniprot.org/uniprot/#_F7CUT1-mappedCitation-17485511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17485511 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLF0-mappedCitation-17485511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17485511 |
| http://purl.uniprot.org/uniprot/#_B1AUV9-mappedCitation-17485511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17485511 |