| http://purl.uniprot.org/citations/17486067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17486067 | http://www.w3.org/2000/01/rdf-schema#comment | "p101, the regulatory subunit of phosphatidylinositol-3-kinase-gamma (PI3Kgamma), was recently reported as a common site of retroviral insertion in T-cell lymphomas induced in mice by MoFe2-MuLV, a unique recombinant gammaretrovirus. The common interruption of p101 by retroviral integration suggests that the locus encodes an oncogene whose altered expression is related to the induction of T-cell malignancy. To examine a possible role in the malignant process, p101 was overexpressed in human T-cell lines Molt-4 and Jurkat. Transient overexpression of p101 induced apoptosis in recipient cells; however, stable expression could be established in cells that expressed moderate levels of p101. Constitutive p101 overexpression in those cells conferred significant protection against ultraviolet-induced apoptosis. Protection against apoptotic induction was attributed to p101-mediated activation of the Akt pathway. Constitutive overexpression of p101 enhanced the activity of p110gamma and further sensitized it to activation upon stimulation of G protein-coupled receptor. These findings are the first to implicate altered expression of p101 in malignancy, specifically in T-cell lymphoma. The findings further provide insight into the regulation of p110gamma, indicating that the stoichiometry of p110gamma and p101 are important in regulating PI3Kgamma signaling."xsd:string |
| http://purl.uniprot.org/citations/17486067 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1210504"xsd:string |
| http://purl.uniprot.org/citations/17486067 | http://purl.uniprot.org/core/author | "Johnson C."xsd:string |
| http://purl.uniprot.org/citations/17486067 | http://purl.uniprot.org/core/author | "Levy L.S."xsd:string |
| http://purl.uniprot.org/citations/17486067 | http://purl.uniprot.org/core/author | "Marriott S.J."xsd:string |
| http://purl.uniprot.org/citations/17486067 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17486067 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/17486067 | http://purl.uniprot.org/core/pages | "7049-7057"xsd:string |
| http://purl.uniprot.org/citations/17486067 | http://purl.uniprot.org/core/title | "Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival."xsd:string |
| http://purl.uniprot.org/citations/17486067 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/17486067 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17486067 |
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| http://purl.uniprot.org/uniprot/#_Q8WYR1-mappedCitation-17486067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17486067 |
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