| http://purl.uniprot.org/citations/17488777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17488777 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurotrophin receptor-interacting MAGE homolog (NRAGE) has been recently identified as a cell-death inducer, involved in molecular events driving cells through apoptotic networks during neuronal development. Recently, we have focused on the functional role of Che-1, also known as apoptosis-antagonizing transcription factor (AATF), a protein involved in cell cycle control and gene transcription. Increasing evidence suggests that Che-1 is involved in apoptotic signalling in neural tissues. In cortical neurons Che-1 exhibits an anti-apoptotic activity, protecting cells from neuronal damage induced by amyloid beta-peptide. Here, we report that Che-1 interacts with NRAGE and that an EGFP-NRAGE fusion protein inhibits nuclear localization of Che-1, by sequestering it within the cytoplasmic compartment. Furthermore, NRAGE overexpression downregulates endogenous Che-1 by targeting it for proteasome-dependent degradation. Finally, we propose that Che-1 is a functional antagonist of NRAGE, because its overexpression completely reverts NRAGE-induced cell-death."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.03454"xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "Bruno T."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "Corbi N."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "De Nicola F."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "Fanciulli M."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "Floridi A."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "Iezzi S."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "Mattei E."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "Passananti C."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "Ciotti M.T."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "Di Certo M.G."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/author | "Desantis A."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/pages | "1852-1858"xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/title | "NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death."xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/17488777 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17488777 |
| http://purl.uniprot.org/citations/17488777 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17488777 |
| http://purl.uniprot.org/uniprot/Q9JKX4#attribution-6FE57E2527E546B16AE050A507D58328 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17488777 |
| http://purl.uniprot.org/uniprot/Q9QYH6#attribution-948B1B9B1369A6F165D1E51156ADA23B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17488777 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG51-mappedCitation-17488777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17488777 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEK0-mappedCitation-17488777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17488777 |