| http://purl.uniprot.org/citations/17490433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17490433 | http://www.w3.org/2000/01/rdf-schema#comment | "Using T-cell receptor (TCR) transgenic mice, we demonstrate that TCR stimulation of naive CD4(+) T cells induces transient T-bet expression, interleukin (IL)-12 receptor beta2 up-regulation, and GATA-3 down-regulation, which leads to T helper (Th)1 differentiation even when the cells are stimulated with peptide-loaded I-A(b)-transfected Chinese hamster ovary cells in the absence of interferon-gamma (IFN-gamma) and IL-12. Sustained IFN-gamma and IL-12 stimulation augments naive T-cell differentiation into Th1 cells. Intriguingly, a significant Th1 response is observed even when T-bet(-/-) naive CD4(+) T cells are stimulated through TCR in the absence of IFN-gamma or IL-12. Stimulation of naive CD4(+) T cells in the absence of IFN-gamma or IL-12 with altered peptide ligand, whose avidity to the TCR is lower than that of original peptide, fails to up-regulate transient T-bet expression, sustains GATA-3 expression, and induces differentiation into Th2 cells. These results support the notion that direct interaction between TCR and peptide-loaded antigen-presenting cells, even in the absence of T-bet expression and costimulatory signals, primarily determine the fate of naive CD4(+) T cells to Th1 cells."xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2567.2007.02630.x"xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/author | "Kikuchi T."xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/author | "Tamura T."xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/author | "Ariga H."xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/author | "Nakada M."xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/author | "Takatsu K."xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/author | "Tokunaga T."xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/author | "Kariyone A."xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/author | "Shimohakamada Y."xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/pages | "210-221"xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/title | "Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals."xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/17490433 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17490433 |
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