| http://purl.uniprot.org/citations/17491591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17491591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17491591 | http://www.w3.org/2000/01/rdf-schema#comment | "Tctex-1, a light-chain component of the cytoplasmic dynein motor complex, can function independently of dynein to regulate multiple steps in neuronal development. However, how dynein-associated and dynein-free pools of Tctex-1 are maintained in the cell is not known. Tctex-1 was recently identified as a Gbetagamma-binding protein and shown to be identical to the receptor-independent activator of G protein signaling AGS2. We propose a novel role for the interaction of Gbetagamma with Tctex-1 in neurite outgrowth. Ectopic expression of either Tctex-1 or Gbetagamma promotes neurite outgrowth whereas interfering with their function inhibits neuritogenesis. Using embryonic mouse brain extracts, we demonstrate an endogenous Gbetagamma-Tctex-1 complex and show that Gbetagamma co-segregates with dynein-free fractions of Tctex-1. Furthermore, Gbeta competes with the dynein intermediate chain for binding to Tctex-1, regulating assembly of Tctex-1 into the dynein motor complex. We propose that Tctex-1 is a novel effector of Gbetagamma, and that Gbetagamma-Tctex-1 complex plays a key role in the dynein-independent function of Tctex-1 in regulating neurite outgrowth in primary hippocampal neurons, most likely by modulating actin and microtubule dynamics."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601716"xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601716"xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Menon S."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Menon S."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Caceres A."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Caceres A."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Sakmar T.P."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Sakmar T.P."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Kastner D.B."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Kastner D.B."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Chuang J.Z."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Chuang J.Z."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Sung C.H."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Sung C.H."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Yeh T.Y."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Yeh T.Y."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Conde C."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Conde C."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Sachdev P."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/author | "Sachdev P."xsd:string |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17491591 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |