| http://purl.uniprot.org/citations/17492053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17492053 | http://www.w3.org/2000/01/rdf-schema#comment | "ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2) isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels predict outcome in patients with acute myocardial infarction or chronic heart failure. Recently, IL-33 was identified as a functional ligand of ST2L, allowing exploration of the role of ST2 in myocardium. We found that IL-33 was a biomechanically induced protein predominantly synthesized by cardiac fibroblasts. IL-33 markedly antagonized angiotensin II- and phenylephrine-induced cardiomyocyte hypertrophy. Although IL-33 activated NF-kappaB, it inhibited angiotensin II- and phenylephrine-induced phosphorylation of inhibitor of NF-kappa B alpha (I kappa B alpha) and NF-kappaB nuclear binding activity. sST2 blocked antihypertrophic effects of IL-33, indicating that sST2 functions in myocardium as a soluble decoy receptor. Following pressure overload by transverse aortic constriction (TAC), ST2(-/-) mice had more left ventricular hypertrophy, more chamber dilation, reduced fractional shortening, more fibrosis, and impaired survival compared with WT littermates. Furthermore, recombinant IL-33 treatment reduced hypertrophy and fibrosis and improved survival after TAC in WT mice, but not in ST2(-/-) littermates. Thus, IL-33/ST2 signaling is a mechanically activated, cardioprotective fibroblast-cardiomyocyte paracrine system, which we believe to be novel. IL-33 may have therapeutic potential for beneficially regulating the myocardial response to overload."xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci30634"xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/author | "Lee R.T."xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/author | "Schreiter E.R."xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/author | "Higgins L.J."xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/author | "McKenzie A.N."xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/author | "Sanada S."xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/author | "Hakuno D."xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/pages | "1538-1549"xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/title | "IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system."xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/17492053 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17492053 |
| http://purl.uniprot.org/citations/17492053 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17492053 |
| http://purl.uniprot.org/uniprot/Q62611#attribution-28DEB5A5807B967E94E7A4150376F548 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17492053 |
| http://purl.uniprot.org/uniprot/Q66H70#attribution-28DEB5A5807B967E94E7A4150376F548 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17492053 |
| http://purl.uniprot.org/uniprot/#_A0A096MIT4-mappedCitation-17492053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17492053 |
| http://purl.uniprot.org/uniprot/#_A0A8I5Y068-mappedCitation-17492053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17492053 |
| http://purl.uniprot.org/uniprot/#_D3Z6T7-mappedCitation-17492053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17492053 |
| http://purl.uniprot.org/uniprot/#_F1LR63-mappedCitation-17492053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17492053 |
| http://purl.uniprot.org/uniprot/#_G3UYU3-mappedCitation-17492053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17492053 |
| http://purl.uniprot.org/uniprot/#_E9M2E8-mappedCitation-17492053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17492053 |
| http://purl.uniprot.org/uniprot/#_H3BLN5-mappedCitation-17492053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17492053 |