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| http://purl.uniprot.org/citations/17498065 | http://www.w3.org/2000/01/rdf-schema#comment | "The asymmetrical structure of bent immunoglobulin E (IgE) bound to its high-affinity receptor, Fc epsilon RI, suggests a possible role for this configuration in the regulation of signaling mediated by cross-linking of Fc epsilon RI on the surface of mast cells and basophils. Indeed, the presence of bound IgE strongly influences the capacity of cross-linked Fc epsilon RI dimers to trigger mast cell degranulation, implicating orientational constraints by bound IgE. Bivalent ligands that cross-link by binding to bivalent IgE can form linear and cyclic chains of IgE/Fc epsilon RI complexes, and these exhibit only limited capacity to stimulate downstream signaling and degranulation, whereas structurally analogous trivalent ligands, which can form branched networks of cross-linked IgE/Fc epsilon RI complexes, are more effective at cell activation. Long bivalent ligands with flexible spacers can form intramolecular cross-links with IgE, and these stable 1:1 complexes are very potent inhibitors of mast cell degranulation stimulated by multivalent antigen. In contrast, trivalent ligands with rigid double-stranded DNA spacers effectively stimulate degranulation responses in a length-dependent manner, providing direct evidence for receptor transphosphorylation as a key step in the mechanism of signaling by Fc epsilon RI. Thus, studies with chemically defined oligovalent ligands show important features of IgE receptor cross-linking that regulate signaling, leading to mast cell activation."xsd:string |
| http://purl.uniprot.org/citations/17498065 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-065x.2007.00517.x"xsd:string |
| http://purl.uniprot.org/citations/17498065 | http://purl.uniprot.org/core/author | "Sil D."xsd:string |
| http://purl.uniprot.org/citations/17498065 | http://purl.uniprot.org/core/author | "Baird B."xsd:string |
| http://purl.uniprot.org/citations/17498065 | http://purl.uniprot.org/core/author | "Holowka D."xsd:string |
| http://purl.uniprot.org/citations/17498065 | http://purl.uniprot.org/core/author | "Torigoe C."xsd:string |
| http://purl.uniprot.org/citations/17498065 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17498065 | http://purl.uniprot.org/core/name | "Immunol Rev"xsd:string |
| http://purl.uniprot.org/citations/17498065 | http://purl.uniprot.org/core/pages | "269-279"xsd:string |
| http://purl.uniprot.org/citations/17498065 | http://purl.uniprot.org/core/title | "Insights into immunoglobulin E receptor signaling from structurally defined ligands."xsd:string |
| http://purl.uniprot.org/citations/17498065 | http://purl.uniprot.org/core/volume | "217"xsd:string |
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