| http://purl.uniprot.org/citations/17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17498689 | http://www.w3.org/2000/01/rdf-schema#comment | "Centromeric Protein-F (Cenp-F) family members have been identified in organisms from yeast to human. Cenp-F proteins are a component of kinetochores during mitosis, bind to the Rb family of tumor suppressors, and have regulatory effects on the cell cycle and differentiation; however, their role in these processes has not been resolved. Here, we provide evidence that the role of murine Cenp-F (mCenp-F, also known as LEK1) remains largely conserved and that the domains within the C-terminus collectively function to regulate the G2/M cell cycle checkpoint. Overexpression of the C-terminal domain of mCenp-F decreases DNA synthesis. Analyses of deletion mutants of mCenp-F reveal that the complete C-terminal domain is required to delay cell cycle progression at G2/M. Signal transduction pathway profiling experiments indicate that the mCenp-F-mediated cell cycle delay does not involve transcriptional activity of key cell cycle regulators such as Rb, E2F, p53, or Myc. However, endogenous mCenp-F colocalizes with pRb and p107, which demonstrates in vivo protein-protein interaction during cell division. These observations suggest that the domains of the C-terminus of mCenp-F have a conserved function in control of mitotic progression through protein-protein interaction with pocket proteins, thus providing a direct connection between cell cycle regulation and mitotic progression."xsd:string |
| http://purl.uniprot.org/citations/17498689 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2007.03.035"xsd:string |
| http://purl.uniprot.org/citations/17498689 | http://purl.uniprot.org/core/author | "Evans H.J."xsd:string |
| http://purl.uniprot.org/citations/17498689 | http://purl.uniprot.org/core/author | "Goodwin R.L."xsd:string |
| http://purl.uniprot.org/citations/17498689 | http://purl.uniprot.org/core/author | "Edwards L."xsd:string |
| http://purl.uniprot.org/citations/17498689 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17498689 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/17498689 | http://purl.uniprot.org/core/pages | "2427-2437"xsd:string |
| http://purl.uniprot.org/citations/17498689 | http://purl.uniprot.org/core/title | "Conserved C-terminal domains of mCenp-F (LEK1) regulate subcellular localization and mitotic checkpoint delay."xsd:string |
| http://purl.uniprot.org/citations/17498689 | http://purl.uniprot.org/core/volume | "313"xsd:string |
| http://purl.uniprot.org/citations/17498689 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17498689 |
| http://purl.uniprot.org/citations/17498689 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17498689 |
| http://purl.uniprot.org/uniprot/Q155P7#attribution-3BD634DD88E05291DC2D77700C39769B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/Q155P7#attribution-7E32523CFF20AA1E71906E752D5EDEF0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/#_E9Q776-mappedCitation-17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/#_Q155P7-mappedCitation-17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/#_F6V6F0-mappedCitation-17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/#_E9PY14-mappedCitation-17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/#_E9Q3P4-mappedCitation-17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/#_Q3TZQ0-mappedCitation-17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/#_Q9QZ84-mappedCitation-17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/#_Q3TNJ4-mappedCitation-17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/#_Q8BV30-mappedCitation-17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498689 |
| http://purl.uniprot.org/uniprot/#_Q8BVF5-mappedCitation-17498689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498689 |