http://purl.uniprot.org/citations/17498784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/17498784 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveThis study characterizes the expression of the novel biomarker B7-H4 in ovarian cancer tissue, normal ovaries, and benign ovarian tumors, and evaluates its relationship to CA125.MethodsOvarian tissue lysates from 251 patients with ovarian carcinoma were assessed for the levels of B7-H4 and CA125 by ELISA assays. For comparison, ovarian tissues from patients with benign ovarian tumors (n=43) and patients with normal ovaries (n=32) were tested. The marker concentrations were correlated with CA125 expression, clinicopathological variables, and patient outcome.ResultsUsing a cut-off based on the 95th percentile of B7-H4 or CA125 concentration in the control group, B7-H4 was over-expressed in 48% of patients with stage I cancer, 55% of patients with stage II cancer, and 67% of patients with late stage cancer. CA125 was elevated in 31% patients with early stage cancer. B7-H4 was elevated in tumors of 30 patients with early stage cancer that were negative for CA125. The combination of B7-H4 and CA125 identified 56 early stage cancer patients (65%) as positive. Correlation of marker expression to clinical outcome showed that high B7-H4 levels were correlated with poor prognosis. However, the effect was not significant when outcome was adjusted for other clinicopathological variables.ConclusionB7-H4 expression was low in normal ovaries and in benign tumors while half of early stage and two-thirds of late stage cancers over-expressed B7-H4. The data are consistent with previous observations and support further investigation of B7-H4 in the detection of early stage ovarian cancer either alone, or in combination with CA125."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ygyno.2007.03.035"xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/author | "Diamandis E.P."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/author | "Scorilas A."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/author | "Simon I."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/author | "Katsaros D."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/author | "Wolfert R.L."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/author | "Massobrio M."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/author | "Kim N.W."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/author | "Rigault de la Longrais I."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/author | "Sarno M.J."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/name | "Gynecol Oncol"xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/pages | "334-341"xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/title | "B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression."xsd:string |
http://purl.uniprot.org/citations/17498784 | http://purl.uniprot.org/core/volume | "106"xsd:string |
http://purl.uniprot.org/citations/17498784 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17498784 |
http://purl.uniprot.org/citations/17498784 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17498784 |
http://purl.uniprot.org/uniprot/#_Q7Z7D3-mappedCitation-17498784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17498784 |
http://purl.uniprot.org/uniprot/Q7Z7D3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17498784 |